abstract：BACKGROUND:This study explored the relationship between cognitive impairments and their impact on rate of symptom improvement in a 26 week work therapy program. METHOD:Data were abstracted from the archives of 157 outpatients with SCID confirmed DSM-IV diagnoses of schizophrenia or schizoaffective disorder who partici...

journal_title：Schizophrenia research

authors： Bell MD,Tsang HW,Greig T,Bryson G

更新日期：2007-11-01 00:00:00

abstract：:Valid criteria to identify young people who are believed to be at ultra high risk (UHR) of developing a psychotic episode were developed over the last decade. The first randomized controlled trial of treatment in a UHR cohort indicated that specific pharmacotherapy and psychotherapy delayed onset of disorder, and poss...

journal_title：Schizophrenia research

authors： Phillips LJ,McGorry PD,Yuen HP,Ward J,Donovan K,Kelly D,Francey SM,Yung AR

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Recent empirical evidence [Maher, B.A., Manschreck, T.C., Linnert, J., Candela, S., 2005. Quantitative assessment of the frequency of normal associations in the utterances of schizophrenia patients and healthy controls. Schizophrenia Research 78, 219-224] shows that schizophrenia patients produce an elevated...

journal_title：Schizophrenia research

authors： Lenzenweger MF,Miller AB,Maher BA,Manschreck TC

更新日期：2007-09-01 00:00:00

abstract：:There is controversy over whether the incidence rates of schizophrenia and psychotic disorders have changed in recent decades. To detect deviations from trends in incidence, we analysed admission data of patients with an ICD-8/9/10 diagnosis of psychotic disorders in the Canton Zurich / Switzerland, for the period 197...

journal_title：Schizophrenia research

authors： Ajdacic-Gross V,Lauber C,Warnke I,Haker H,Murray RM,Rössler W

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:A definition of clinical remission in schizophrenia has recently been proposed. However, it is also known that neuropsychological (NP) impairments may be better predictors of functional outcomes than clinical symptoms. Understanding the relationship between clinical remission and cognitive improvement may be...

journal_title：Schizophrenia research

authors： Buckley PF,Harvey PD,Bowie CR,Loebel A

更新日期：2007-08-01 00:00:00

abstract：:Vulnerability for schizophrenia is related, in part, to genetic predisposition. The identification of pathophysiological abnormalities associated with the disorder that are also present in unaffected family members of individuals with schizophrenia may assist in delineating the genetic contributions to vulnerability f...

journal_title：Schizophrenia research

authors： Woodward ND,Tibbo P,Purdon SE

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Schizophrenia with an onset in adolescence is known to be associated with a poorer outcome and cognitive difficulties. These impairments have an impact on quality of life and represent treatment targets. Cognitive remediation therapy (CRT) attempts to improve cognitive deficits by teaching information proces...

journal_title：Schizophrenia research

authors： Wykes T,Newton E,Landau S,Rice C,Thompson N,Frangou S

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Negative symptoms in schizophrenia are associated with deficits in executive function and frequently prove highly resistant to neuroleptic medication. Using repetitive transcranial magnetic stimulation (rTMS) to activate the prefrontal cortex has been suggested as a treatment for negative symptoms. METHODS:...

journal_title：Schizophrenia research

authors： Mogg A,Purvis R,Eranti S,Contell F,Taylor JP,Nicholson T,Brown RG,McLoughlin DM

更新日期：2007-07-01 00:00:00

abstract：:The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for s...

journal_title：Schizophrenia research

authors： Guo SZ,Huang K,Shi YY,Tang W,Zhou J,Feng GY,Zhu SM,Liu HJ,Chen Y,Sun XD,He L

更新日期：2007-07-01 00:00:00

abstract：:We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning w...

journal_title：Schizophrenia research

authors： Nestor PG,Onitsuka T,Gurrera RJ,Niznikiewicz M,Frumin M,Shenton ME,McCarley RW

更新日期：2007-03-01 00:00:00

abstract：:The serotonin and dopamine neurotransmitter systems are candidate pathways in the development of schizophrenia because of the assumed causal relationship with the observed symptoms as well as effective targeting of the corresponding receptors by antipsychotic drugs. However, genetic association studies have systematic...

journal_title：Schizophrenia research

authors： Domínguez E,Loza MI,Padín F,Gesteira A,Paz E,Páramo M,Brenlla J,Pumar E,Iglesias F,Cibeira A,Castro M,Caruncho H,Carracedo A,Costas J

更新日期：2007-02-01 00:00:00

abstract：:Prospective, double-blind, randomized trials comparing atypical antipsychotic drugs (APDs) to typical APDs, such as haloperidol, indicate that atypical APDs provide a modest benefit to cognitive function in schizophrenia. However, the validity of this inference has been contested by suggestions that the cognitive impr...

journal_title：Schizophrenia research

authors： Woodward ND,Purdon SE,Meltzer HY,Zald DH

更新日期：2007-01-01 00:00:00

abstract：:Minor physical anomalies (MPAs) are more prevalent amongst individuals with psychosis, supporting a neurodevelopmental model for psychotic disorders. The aim of this study was to investigate the possibility that neurodevelopmental adversity contributes to the excess of psychosis found in some ethnic groups in the UK. ...

journal_title：Schizophrenia research

authors： Dean K,Dazzan P,Lloyd T,Morgan C,Morgan K,Doody GA,Hutchinson G,Orr K,Jones PB,Murray RM,Fearon P

更新日期：2007-01-01 00:00:00

abstract：:Genetic factors that modulate the immune response have been implicated as risk factors for schizophrenia and cognitive impairment. We assessed the correlation between cognitive functioning and the LTA Cys13Arg polymorphism in 351 individuals with schizophrenia, 122 with bipolar disorder, and 160 controls. There was a ...

journal_title：Schizophrenia research

authors： Dickerson F,Boronow J,Stallings C,Origoni A,Yolken R

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Metabolic abnormalities and weight gain are an important problem in patients with schizophrenia. An instrument to evaluate body image and self-esteem related to weight has recently been developed (B-WISE). The first objective was to evaluate whether the findings of the original validation study could be conf...

journal_title：Schizophrenia research

authors： De Hert M,Peuskens B,van Winkel R,Kalnicka D,Hanssens L,Van Eyck D,Wyckaert S,Peuskens J

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Atypical antipsychotics clozapine, olanzapine, and quetiapine have significant affinity for the muscarinic receptors in vitro, while aripiprazole, risperidone, and ziprasidone do not. Dissimilarity in binding profiles may contribute to the reported differences in the anticholinergic effects of these antipsyc...

journal_title：Schizophrenia research

authors： Chew ML,Mulsant BH,Pollock BG,Lehman ME,Greenspan A,Kirshner MA,Bies RR,Kapur S,Gharabawi G

更新日期：2006-12-01 00:00:00

abstract：:Recent studies have proposed that difficulty with accessing the lexical-semantic memory store may underpin some of the specific linguistic problems associated with formal thought disorder (FTD). We examined the consistency of name retrieval as an indicator of the ability to access lexical-semantic knowledge in patient...

journal_title：Schizophrenia research

authors： Leeson VC,Laws KR,McKenna PJ

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:For adults with schizophrenia, comorbidity is common and contributes to impairment. Thus, there has been an increasing effort to identify and treat comorbid symptoms. This report extends that work by examining comorbidity in children and young adolescents with childhood-onset schizophrenia. METHODS:Eighty-t...

journal_title：Schizophrenia research

authors： Ross RG,Heinlein S,Tregellas H

更新日期：2006-12-01 00:00:00

abstract：:Studies of the risk of schizophrenia and related non-affective psychoses among individuals exposed to head injury have reported conflicting findings. The diagnostic specificity of reported associations remains unclear and the effects of sex, genetic vulnerability and timing of exposures are also uncertain. The authors...

journal_title：Schizophrenia research

authors： Harrison G,Whitley E,Rasmussen F,Lewis G,Dalman C,Gunnell D

更新日期：2006-12-01 00:00:00

abstract：:Transient working memory requires attention and temporary storage of information, whereas executive function working memory requires additional mental manipulation of that information. Working memory impairment is common in schizophrenia patients, but only some studies have found differential impairment in executive f...

journal_title：Schizophrenia research

authors： Twamley EW,Palmer BW,Jeste DV,Taylor MJ,Heaton RK

更新日期：2006-10-01 00:00:00

abstract：:This study determines that visuospatial working memory (VSWM) deficits are evident in adolescent-onset schizophrenia, while the spatial strategy and spatial span components of VSWM are spared. These findings imply that frontal-striatal-parietal neural networks are dysfunctional in adolescent-onset schizophrenia, while...

journal_title：Schizophrenia research

authors： Vance A,Hall N,Bellgrove MA,Casey M,Karsz F,Maruff P

更新日期：2006-10-01 00:00:00

abstract：:Results of first-episode psychosis studies have shown that the diagnosis of schizophrenia is more stable across time than other diagnoses within the psychosis spectrum disorders. The objective of this study was to determine the diagnostic stability in a sample of first-episode patients and to determine the factors tha...

journal_title：Schizophrenia research

authors： Addington J,Chaves A,Addington D

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:Strategic and mnemonic abilities of person with schizophrenia (SCZ) were studied using a part-list cuing (PLC) task. In this task, presentation of retrieval cues in the form of a subset of studied words typically impairs recall of the remaining items. This impairment is thought to reflect a disruption of partic...

journal_title：Schizophrenia research

authors： Christensen BK,Girard TA,Benjamin AS,Vidailhet P

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to test the goodness-of-fit of all previously published five-factor models of the Positive and Negative Syndrome Scale (PANSS). METHODS:We used confirmatory factor analysis (CFA) with a large data set (N = 5769). RESULTS:The different subsamples were tested for heterogeneity and we...

journal_title：Schizophrenia research

authors： van der Gaag M,Cuijpers A,Hoffman T,Remijsen M,Hijman R,de Haan L,van Meijel B,van Harten PN,Valmaggia L,de Hert M,Wiersma D

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Biochemical, physiological and genetic evidence suggests dysregulation of central nicotinic acetylcholine receptor (nAChR) systems in schizophrenia, which may contribute to neuropsychological dysfunction and the high rates of smoking in this disorder. To evaluate the effects of nAChR blockade on neuropsychol...

journal_title：Schizophrenia research

authors： Sacco KA,Termine A,Dudas MM,Seyal AA,Allen TM,Vessicchio JC,Wexler BE,George TP

更新日期：2006-07-01 00:00:00

abstract：UNLABELLED:Studies on personality profiles in psychosis typically report certain personality traits as linked to the disorder. OBJECTIVES:To determine if individuals with a first episode of psychosis: 1) differ from a non-clinical group on the five factor model of personality; 2) all present with similar personality p...

journal_title：Schizophrenia research

authors： Beauchamp MC,Lecomte T,Lecomte C,Leclerc C,Corbière M

更新日期：2006-07-01 00:00:00

abstract：:Studying Klinefelter syndrome (47,XXY), a genetically defined disorder characterized by the presence of an additional X chromosome, can reveal insights into genotype-phenotype associations. Increased vulnerability to psychiatric disorders characterized by difficulties in social interactions, such as schizophrenia and ...

journal_title：Schizophrenia research

authors： van Rijn S,Swaab H,Aleman A,Kahn RS

更新日期：2006-06-01 00:00:00

abstract：:This paper examines the psychometric properties (reliability and factor structure) and validity (relationship with various self-report measures and SPEM dysfunction) of the SSQ or Schizotypic Syndrome Questionnaire, a 108-item inventory for the measurement of 12 prodromal or schizotypic symptoms present in Van Kampen'...

journal_title：Schizophrenia research

authors： van Kampen D

更新日期：2006-06-01 00:00:00

abstract：:Task set maintenance and switching deficits are robust in schizophrenia. However, little is known about how these constructs are related to one another. The development of an improved understanding of set switching and maintenance deficits in schizophrenia requires that these constructs be explicated in terms of eleme...

journal_title：Schizophrenia research

authors： Kieffaber PD,Kappenman ES,Bodkins M,Shekhar A,O'Donnell BF,Hetrick WP

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:Despite an increased risk for suicide among individuals diagnosed with psychotic disorders, risk factors for completed suicide remain largely unexamined in this population. Using a case-control design, this study aimed to investigate clinical and behavioural risk factors for suicide completion in schizophreni...

journal_title：Schizophrenia research

authors： McGirr A,Tousignant M,Routhier D,Pouliot L,Chawky N,Margolese HC,Turecki G

更新日期：2006-05-01 00:00:00

abstract：:The purpose of this study was to determine if patients with schizophrenia or schizoaffective disorders and comorbid posttraumatic stress disorder (PTSD) are at higher risk for suicidality than patients without comorbid PTSD. Participants were 165 male veterans with primary diagnoses of schizophrenia or schizoaffective...

journal_title：Schizophrenia research

authors： Strauss JL,Calhoun PS,Marx CE,Stechuchak KM,Oddone EZ,Swartz MS,Butterfield MI

更新日期：2006-05-01 00:00:00

abstract：:It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant ...

journal_title：Schizophrenia research

authors： Takahashi N,Ishihara R,Saito S,Maemo N,Aoyama N,Ji X,Miura H,Ikeda M,Iwata N,Suzuki T,Kitajima T,Yamanouchi Y,Kinoshita Y,Ozaki N,Inada T

更新日期：2006-04-01 00:00:00

abstract：:In view of prior reports suggesting associations between polymorphisms of the tumor necrosis factor gene (TNF) and schizophrenia, we sequenced all exons, introns and 7 kb flanking sequence at TNF in DNA pooled from 125 Caucasian schizophrenia cases and 200 controls. We identified 18 SNPs of which we selected and genot...

journal_title：Schizophrenia research

authors： Shirts BH,Bamne M,Kim JJ,Talkowski M,Wood J,Yolken R,Nimgaonkar VL

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Many patients recovering from a first psychotic episode will discontinue medication against medical advice, even before a 1-year treatment course is completed. Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, ...

journal_title：Schizophrenia research

authors： Perkins DO,Johnson JL,Hamer RM,Zipursky RB,Keefe RS,Centorrhino F,Green AI,Glick IB,Kahn RS,Sharma T,Tohen M,McEvoy JP,Weiden PJ,Lieberman JA,HGDH Research Group.

更新日期：2006-03-01 00:00:00

abstract：:Several investigations suggest that complexin may be a schizophrenia-susceptibility factor. We conducted a genetic association analysis between complexin genes (CPLX1 and CPLX2) and schizophrenia in Japanese patients (377 cases and 341 controls). Ten and eleven haplotype-tagging (ht)SNPs in CPLX1 and CPLX2, respective...

journal_title：Schizophrenia research

authors： Kishi T,Ikeda M,Suzuki T,Kitajima T,Yamanouchi Y,Kinoshita Y,Ozaki N,Iwata N

更新日期：2006-02-28 00:00:00

abstract：:Motion-induced blindness (MIB) occurs when target stimuli are presented together with a moving distractor pattern. Most observers experience the targets disappearing and reappearing repeatedly for periods of up to several seconds. MIB can be viewed as a striking marker for the organization of cognitive functioning. In...

journal_title：Schizophrenia research

authors： Tschacher W,Schuler D,Junghan U

更新日期：2006-01-31 00:00:00

abstract：:There is considerable inconsistency in findings regarding the relationship between specific cognitive deficits and social impairment in patients with schizophrenia. This inconsistency may relate to variability across studies in how social functioning is measured and preliminary evidence suggests that different indices...

journal_title：Schizophrenia research

authors： Cohen AS,Forbes CB,Mann MC,Blanchard JJ

更新日期：2006-01-31 00:00:00

abstract：:We examined the fractionation of executive functioning performance in ninety patients with schizophrenia, who were tested for initiation, sustained attention, switching/flexibility, attention allocation and impulsivity/disinhibition. The participants were also given tests of general intelligence and memory. We analyse...

journal_title：Schizophrenia research

authors： Chan RC,Chen EY,Cheung EF,Chen RY,Cheung HK

更新日期：2006-01-31 00:00:00

abstract：:A number of recent studies have suggested that schizophrenia patients share metamemory deficits, particularly, a decreased ability to distinguish between errors and correct responses in terms of response confidence (i.e., decreased confidence gap): patients are over-confident in errors while at the same time being und...

journal_title：Schizophrenia research

authors： Moritz S,Woodward TS,Chen E

更新日期：2006-01-31 00:00:00

abstract：BACKGROUND:Family studies have suggested that schizophrenia and bipolar disorders share some susceptibility factors. Schizotypal personality disorder (SPD) may be an intermediate phenotype common both to schizophrenia and bipolar disorders. We explored the familiality of schizotypal dimensions by comparing the magnitud...

journal_title：Schizophrenia research

authors： Schürhoff F,Laguerre A,Szöke A,Méary A,Leboyer M

更新日期：2005-12-15 00:00:00